Recent Relevant Publications

Deng, Y.*, Foley, E.M.*, Gonzales, J.C.*, Gordts, P.L., Li, Y., Esko, J.D. (2012) Shedding of syndecan-1 from human hepatocytes alters VLDL clearance. Hepatology 55:277-86

Lawrence, R., Brown. J.R., Al-Mafraji, K., Lamanna, W.C., Beitel, J.R., Boons, G.-J., Esko, J.D. and Crawford, B.E. (2012) Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nature Chem Biol. 8:197-204 News and Views: L. Kjellén (2012) Glycobiology: Enzyme deficiencies deciphered. Nature Chem Biol 8:137-138

Kowalewskia, B., Lamanna. W.C., Lawrence, R., Dammea,M., Stroobantsc, S., Padvad, M., Kalusa, I., Fresea, M.A., Lübkea, T., Lüllmann-Rauche, R., D’Hoogec, R., Esko, J.D., and Dierk, T. (2012) Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc. Natl. Acad. Sci. USA 109:10310-10315

Axelsson, J., Xu, D., Kang, B.N., Nussbacher, J.K.*, Handel, T.M., Ley, K., Sriramarao, P., Esko, J.D. (2012) Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 120:1742-51

Lamanna, W.C., Lawrence, R., Sarrazin, S., Lameda-Diaz, C.†, Gordts, P.L., Moremen, K.W., Esko, J.D. (2012) A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 287:36283-90.

Inoue, M., Tong, W., Esko, J.D., and Tor, Y. (2013) Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol., in press.

Xu, D., Young, J.H., Krahn, J.H., Song, D., Corbett, K.D., Chazin, W.J., Pedersen, L.C. and Esko, J.D. (2013) Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. [Epub ahead of print].

Gonzales, J.C.*, Gordts, P.L., Foley, E.M.* and Esko, J.D. (2013) Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J. Clin Invest., 23:2742-2751.

Foley, E.M.*, Gordts, P.L., Stanford, K.I.*, Gonzales, J.C.*, Lawrence, R., Stoddard, N.* and Esko, J.D. (2013) Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 33:2065-2074.

Zhang, B., Xiao, W., Qiu, H., Zhang, F., Moniz, H.A., Jaworski, A., Condac, E., Gutierrez-Sanchez, G., Heiss, C., Clugston, R.D., Azadi, P., Greer, J.J., Bergmann, C., Moremen, K.W., Li, D., Linhardt, R.J., Esko, J.D. and Wang, L. (2013) Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 124:209-21

Inoue, M., Wexselblatt, E., Esko, J.D. and Tor, Y. (2014) Macromolecular uptake of alkyl-chain-modified guanidinoglycoside molecular transporters. Chembiochem. 15:676-680

Gordts, P.L.S.M., Foley, E.*, Lawrence, R., Sinha, R.†, Lameda-Diaz, C.†, Deng, L., Nock, R., Glass, C.K., Erbilgin, A., Lusis, A.J., Witztum, J.L. and Esko, J.D. (2014) Reducing Macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced Type I interferon signaling. Cell Metab. In press

Thacker, B.E.*, Xu, D., Lawrence, R. and Esko, J.D. (2014) Heparan sulfate 3-O-sulfation: A structure in search of a function. Matrix Biol. 35:60-72

Lawrence, R., Brown, J.R., Lorey, F., Dickson, P.I., Crawford, B.E., and Esko, J.D. (2014) Glycan-based biomarkers for mucopolysaccharidoses. Molec. Gene. Metabolism 111:73-83

Xu, D. and Esko, J.D. (2014) Demystifying heparan-sulfate protein interactions.
Ann. Rev. Biochem. 83:129-57

* indicates graduate students
† indicates undergraduate students