Recent Relevant Publications

  • Essentials of Glycobiology, 2nd Edition, Edited by Varki, A., Cummings, R., Esko, J.D., Freeze, H.H., Stanley, P., Bertozzi, C., Hart, G.W., and Etzler, M.E. Cold Spring Harbor Laboratory Press, New York, 2009.

  • Xu, D., Fuster, M.M., Lawrence, R., and Esko, J.D. (2011) Heparan sulfate regulates VEGF165 and VEGF121-mediated vascular hyperpermeability. J Biol Chem. 286:737-745

  • Zak, B.M.*, Schuksz, M.*, Koyama, E., Mundy, C., Wells, D.E., Yamaguchi, Y., Pacifici, M., Esko, J.D. (2011) Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones. Bone 48:979-987

  • Garner, O.B.*, Bush, K.T., Nigam, K.B., Yamaguchi, Y., Xu, D., Esko, J.D., Nigam, S.K. (2011) Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 355:394-403

  • Chang, Y.-C., Wang, Z., Flax, L.A., Xu, D., Esko, J.D., Nizet, V., and Baron, M.J. (2011) Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathogens. 7:e1002082; Featured article

  • Deng, Y.*, Foley, E.M.*, Gonzales, J.C.*, Gordts, P.L., Li, Y., Esko, J.D. (2011) Shedding of syndecan-1 from human hepatocytes alters VLDL clearance. Hepatology 55:277-86

  • Xu, D, Young, J.†, Song, D., Esko, J.D. (2011) Heparan sulfate is essential for high mobility group protein-1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE). J. Biol. Chem. 286:41736-41744

  • Lawrence, R., Brown. J.R., Al-Mafraji, K., Lamanna, W.C., Beitel, J.R., Boons, G.-J., Esko, J.D. and Crawford, B.E. (2011) Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nature Chem Biol. 8:197-204 News and Views: L. Kjellén (2012) Glycobiology: Enzyme deficiencies deciphered. Nature Chem Biol 8:137-138

  • Kowalewskia, B., Lamanna. W.C., Lawrence, R., Dammea,M., Stroobantsc, S., Padvad, M., Kalusa, I., Fresea, M.A., Lübkea, T., Lüllmann-Rauche, R., D’Hoogec, R., Esko, J.D., and Dierk, T. (2012) Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc. Natl. Acad. Sci. USA 109:10310-10315

  • Bergfeld, A.K., Pearce, O.M., Diaz, S.L., Lawrence, R., Vocadlo, D.J., Choudhury, B., Esko, J.D., Varki, A. (2012) Metabolism of vertebrate amino sugars with N-glycolyl groups: Incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. J Biol Chem. 287(34):28898-916

  • Axelsson, J., Xu, D., Kang, B.N., Nussbacher, J.K.*, Handel, T.M., Ley, K., Sriramarao, P., Esko, J.D. (2012) Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 120:1742-51

  • Bush, K.T., Crawford, B.E., Garner, O.B., Nigam, K.B., Esko, J.D., Nigam, S.K. (2012) N-Sulfation of Heparan Sulfate Regulates Early Branching Events in the Developing Mammary Gland. J Biol Chem. [Epub ahead of print]

  • Lamanna, W.C., Lawrence, R., Sarrazin, S., Lameda-Diaz, C.†, Gordts, P.L., Moremen, K.W., Esko, J.D. (2012) A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 287:36283-90.

* indicates graduate students
† indicates undergraduate students