Recent Relevant Publications

Wexselblatt, E., Esko, J.D., and Tor, Y. (2015) GNeosomes: Highly lysosomotropic nanoassemblies for lysosomal delivery. ACS Nano. 9:3961-3968.

Akizu, N., Cantagrel, V., Zaki, M.S., Al-Gazali, L., Wang, X., Rosti, R.O., Dikoglu, E., Gelot, A.B., Rosti, B., Vaux, K.K., Scott, E.M., Silhavy, J.L., Schroth, J., Copeland, B., Schaffer, A.E., Gordts, P.L., Esko, J.D., Buschman, M.D., Field, S.J., Napolitano, G., Abdel-Salam, G.M., Ozgul, R.K., Sagiroglu, M.S., Azam, M., Ismail, S., Aglan, M., Selim, L., Mahmoud, I.G., Abdel-Hadi, S., Badawy, A.E., Sadek, A.A., Mojahedi, F., Kayserili, H., Masri, A., Bastaki, L., Temtamy, S., Müller, U., Desguerre, I., Casanova, J.L., Dursun, A., Gunel, M., Gabriel, S.B., de Lonlay, P., and Gleeson, J.G. (2015) Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat. Genet. 47:528-534.

Doody, K.M., Stanford, S.M., Sacchetti, C.D., Svensson, M.N., Coles, C.H., Mitakidis, N., Kiosses, W.B., Bartok, B., Fos, C., Cory, E., Sah, R.L., Liu-Bryan, R., Boyle, D.L., Arnett, H.A., Mustelin, T., Corr, M., Esko, J.D., Tremblay, M.L., Firestein, G.S., Aricescu, A.R. and Bottini, N. (2015) Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci. Transl. Med. 7:288. Awarded 2016 Lee C. Howley Sr. Prize for Arthritis Scientific Research, Arthritis Foundation

Coulson-Thomas, V.J., Chang, S.H., Yeh, L.K., Coulson-Thomas, Y.M., Yamaguchi, Y., Esko, J., Liu, C.Y. and Kao, W. (2015) Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest. Ophthalmol. Vis. Sci. 56:3004-3014.

Xu, D., Olson, J., Cole, J.N., van Wijk, X.M., Brinkmann, V., Zychlinsky, A., Nizet, V., Esko, J.D., and Chang, Y.C. (2015) Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity. Infect Immun. 83:3648-3656.

Weiss, R.J.*, Gordts, P.L.S.M., Le, D., Xu, D., Esko, J.D. and Tor, Y. (2015) Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions. Chem. Sci. 6:5984-5993.

Zaiss, A.K., Foley, E.M.*, Lawrence, R., Schneider, L.S., Hoveida, H., Secrest, P., Catapang, A.B., Yamaguchi, Y., Alemany, R., Shayakhmetov, D.M., Esko, J.D., and Herschman, H.R. (2015) Hepatocyte heparan sulfate is required for adeno-associated virus 2 but dispensable for adenovirus 5 liver transduction in vivo. J. Virol. 90:412-420.

Marki, A., Esko, J.D., Pries, A.R., and Ley, K. (2015) Role of the endothelial surface layer in neutrophil recruitment. J. Leukoc. Biol. 98:503-15

Varki, A., Cummings, R.D., Aebi, M, Packer, N.H., Seeberger, P.H., Esko, J.D., Stanley, P., Hart, G., Darvill, A., Kinoshita, T., Prestegard, J.J., Schnaar, R.L., Freeze, H.H., Marth, J.D., Bertozzi, C.R., Etzler, M.E., Frank, M., Vliegenthart, J.F.G., Lütteke, T., Perez, S., Bolton, E., Rudd, P., Paulson, J., Kanehisa, M., Toukach, P., Aoki-Kinoshita, K.F., Dell, A., Narimatsu, H., York, W., Taniguchi, N., and Kornfeld, S. (2015) Symbol nomenclature for graphical representations of glycans. Glycobiology 25:1323-1324.

Thacker, B.E.*, Seamen, E., Lawrence, R., Parker, M.W., Xu, Y., Liu, J., Vander Kooi, C.W., and Esko, J.D. (2016) Expanding the 3-O-sulfate proteome - Enhanced binding of neuropilin-1 to 3-O-sulfated heparan sulfate modulates its activity. ACS Chem. Biol. 11:971-980.

Hamill, K.M.*, McCoy, L.S., Wexselblatt, E., Esko, J.D. and Tor, Y. (2016) Polymyxins facilitate entry into mammalian cells. Chem. Sci. 7:5059-5068.

Gordts, P.L., Nock, R.†, Son, N.H., Ramms, B.*, Lew, I.†, Gonzales, J.C.*, Thacker, B.E.*, Basu, D., Lee, R.G., Mullick, A.E., Graham, M.J., Goldberg, I.J., Crooke, R.M., Witztum, J.L. and Esko, J.D. (2016) ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J. Clin. Invest. 26:2855-2866.

Hamill, K.M.*, Wexselblatt, E., Tong, W., Esko, J.D. and Tor, Y. (2016) Delivery of an active lysosomal enzyme using GNeosomes. J. Mater. Chem. B. 4:5794-5797.

Dwyer, C.A. and Esko, J.D. (2016) Glycan susceptibility factors in autism spectrum disorders. Mol. Aspects Med. 51:104-114.

van Wijk, X.M., Döhrmann, S., Hallström, B.M., Li, S., Voldborg, B.G., Meng, B.X.†, McKee, K.K., van Kuppevelt, T.H., Yurchenco, P.D., Palsson, B.O., Lewis, N.E., Nizet, V. and Esko, J.D. (2017) Whole genome sequencing of invasion-resistant cells identifies laminin a2 as a host factor for bacterial invasion. MBio 8:e02128-16.

Dhamale, O.P., Lawrence, R., Wiegmann, E.M., Shah, B.A., Al-Mafraji, K., Lamanna, W.C., Lübke, T., Dierks, T., Boons, G.-J. and Esko, J.D. (2017) Arylsulfatase K is the lysosomal 2-sulfoglucuronate sulfatase. ACS Chem. Biol. 12:367-373.

Dwyer, C.A., Scudder, S.L., Lin, Y., Dozier, L.E., Phan, D. Allen, N.J., Patrick, G.N. and Esko, J.D. (2017) Neurodevelopmental changes in excitatory synaptic structure and function in the cerebral cortex of Sanfilippo Syndrome IIIA mice. Sci. Rep. 7:46576.

Hamill, K.M., Wexselblatt, E., Tong, W., Esko, J.D. and Tor, Y. (2017) Delivery of cargo to lysosomes using GNeosomes. Meth. Molec. Biol. 1594:151-163.

Weiss, R.J., Esko J.D. and Tor, Y. (2017) Targeting heparin and heparan sulfate protein interactions. Org Biomol Chem. 5:5656-5668.

* indicates graduate students
indicates undergraduate students