Recent Relevant Publications

Inoue, M., Tong, W., Esko, J.D., and Tor, Y. (2013) Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol., 8:1383-1388

Xu, D., Young, J.H., Krahn, J.H., Song, D., Corbett, K.D., Chazin, W.J., Pedersen, L.C. and Esko, J.D. (2013) Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol., 8:1611-1620

Gonzales, J.C.*, Gordts, P.L., Foley, E.M.* and Esko, J.D. (2013) Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J. Clin Invest., 23:2742-2751.

Foley, E.M.*, Gordts, P.L., Stanford, K.I.*, Gonzales, J.C.*, Lawrence, R., Stoddard, N.* and Esko, J.D. (2013) Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 33:2065-2074.

Zhang, B., Xiao, W., Qiu, H., Zhang, F., Moniz, H.A., Jaworski, A., Condac, E., Gutierrez-Sanchez, G., Heiss, C., Clugston, R.D., Azadi, P., Greer, J.J., Bergmann, C., Moremen, K.W., Li, D., Linhardt, R.J., Esko, J.D. and Wang, L. (2013) Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 124:209-21

Inoue, M., Wexselblatt, E., Esko, J.D. and Tor, Y. (2014) Macromolecular uptake of alkyl-chain-modified guanidinoglycoside molecular transporters. Chembiochem. 15:676-680

Wen, J., Xiao, J., Rahdar, M., Choudhury, B.P., Cui, J., Taylor, G.S., Esko, J.D., and Dixon, J.E. (2014) Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A 111:15723-15728

Gordts, P.L.S.M., Foley, E.*, Lawrence, R., Sinha, R., Lameda-Diaz, C., Deng, L., Nock, R., Glass, C.K., Erbilgin, A., Lusis, A.J., Witztum, J.L. and Esko, J.D. (2014) Reducing Macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced Type I interferon signaling. Cell Metab. 20, 813–826. Highlighted in: N. R. Gough (2014) Heparan sulfate proteoglycans control basal inflammation. 
Sci. Signal. 7, ec320

Thacker, B.E.*, Xu, D., Lawrence, R. and Esko, J.D. (2014) Heparan sulfate 3-O-sulfation: A structure in search of a function. Matrix Biol. 35:60-72

Lawrence, R., Brown, J.R., Lorey, F., Dickson, P.I., Crawford, B.E., and Esko, J.D. (2014) Glycan-based biomarkers for mucopolysaccharidoses. Molec. Gene. Metabolism 111:73-83

Xu, D. and Esko, J.D. (2014) Demystifying heparan-sulfate protein interactions.
Ann. Rev. Biochem. 83:129-57

Mooij, H.L., Bernelot Moens, S.J., Gordts, P.L., Stanford, K.I.*, Foley, E.M.*, van den Boogert, M.A., Witjes, J.J., Hassing, H.C., Tanck, M.W., van de Sande, M.A., Levels, J.H., Kastelein, J.J., Stroes, E.S., Dallinga-Thie, G.M., Esko, J.D. and Nieuwdorp, M. (2015) Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J. Lipid Res. 56:665-673.

Wexselblatt, E., Esko, J.D. and Tor, Y. (2015) GNeosomes: Highly lysosomotropic nanoassemblies for lysosomal delivery. ACS Nano 9:3961-3968

Xu, D., Olson, J., Cole, J.N., van Wijk, X.M., Brinkmann, V., Zychlinsky, A., Nizet, V., Esko, J.D. and Chang, Y.C. (2015) Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity.
Infect Immun. 83:3648-365

Marki, A., Esko, J.D., Pries, A.R. and Ley, K. (2015) Role of the endothelial surface layer in neutrophil recruitment. J. Leukoc. Biol. In press

* indicates graduate students
indicates undergraduate students