Recent Relevant Publications

Sandoval, D.R., Toledo, A., Painter, C.D., Tota, E.M., Sheikh, M.O., West, A.M.V., Frank, M.M., Wells, L., Xu, D., Bicknell, R., Corbett, K.D. and Esko, J.D. (2020) Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin binding protein. J. Biol. Chem. 295:2804-2821. PMID:31964714. Selected for a special virtual issue.

Sevillano, A.M., Aguilar-Calvo, P., Kurt, T.D., Lawrence, J.A., Soldau, K., Nam, T.H., Schumann, T., Pizzo, D.P., Nyström, S., Choudhury, B., Altmeppen, H., Esko, J.D., Glatzel, M., Nilsson, K.P.R. and Sigurdson, C.J. (2020) Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease. J. Clin. Invest. 130:1350-1362. PMID:31985492; Reviewed in Bartz JC. (2020) Underglycosylated prion protein modulates plaque formation in the brain. J. Clin. Invest. 130:1350-1362 PMID:31985491

Weiss, R.J., Spahn, P.N., Chiang, A.W.T., Li , J., Kellman, B.P., Benner, C., Glass, C.K., Gordts, P.L.S.M., Lewis, N.E. and Esko, J.D. (2020) ZNF263 is a novel transcriptional regulator of heparin biosynthesis. Proc. Natl. Acad. Sci. 117:9311-9317. PMID: 32277030

Callender, J.A., Sevillano, A.M., Soldau, K., Kurt, T.D., Schumann, T., Pizzo, D.P., Altmeppen, H., Glatzel, M., Esko, J.D. and Sigurdson, C.J. (2020) Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease. Neurobiol. Dis. 142:104955. PMID:32454127

Clausen, T.M., Sandoval, D.R., Spliid, C.B., Pihl, J., Painter, C.D., Thacker, B.E., Glass, C.A., Narayanan, A., Majowicz, S.A., Zhang, Y., Torres, J.L., Golden, G.J., Porell, R., Garretson, A.F., Laubach, L., Feldman, J., Yin, X., Pu, Y., Hauser, B., Caradonna, T.M., Kellman, B.P., Martino, C., Gordts, P.L.S.M., Leibel, S.L., Chanda, S.K., Schmidt, A.G., Godula, K., Jose, J., Corbett, K.D., Ward, A.B., Carlin, A.F. and Esko, J.D. (2020) SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2. Cell 83:1043-1057. PMID: 32699853

Spliid ,C.B., Toledo, A.G., Salanti, A., Esko, J.D. and Clausen, T.M. (2021) Beware, commercial chondroitinases vary in activity and substrate specificity. Glycobiology 31:103-115. PMID:32573715

Marki, A., Buscher, K., Lorenzini, C., Meyer, M., Saigusa, R., Fan, Z., Yeh, Y.T., Hartmann, N., Dan, J.M., Kiosses, W.B., Golden, G.J., Ganesan, R., Winkels, H., Orecchioni, M., McArdle, S., Mikulski, Z., Altman, Y., Bui, J., Kronenberg, M., Chien, S., Esko, J.D., Nizet, V., Smalley, D., Roth, J. and Ley, K. (2021) Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. J. Exp. Med. 218:e20200551. PMID:33275138

Toledo, A.G., Sorrentino, J.T., Sandoval, D.R., Malmström, J., Lewis, N.E. and Esko, J.D. (2021) A systems view of the heparan sulfate interactome. J. Histol. Histochem. 69:105-119. PMID: 33494649

Weiss, R.J., Spahn, P.N., Chiang, A.W.T., Liu, Q., Li , J., Hamill, K.M., Rother, S., Clausen, T.M., Hoeksema, M.A., Timm, B.M., Godula, K., Glass, C.K., Tor, Y., Gordts, P.S.L.M., Lewis, N.E. and Esko, J.D. (2021) Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat. Chem. Biol. 17:684-692. PMID: 33846619

Karlsson, R., Chopra, P., Joshi, A., Yang, Z., Vakhrushev, S.Y., Clausen, T.M., Painter, C.D., Szekeres, G.P., Chen, Y.H., Sandoval, D.R., Hansen, L., Esko, J.D., Pagel, K., Dyer, D.P., Turnbull, J.E., Clausen, H., Boons, G.J. and Miller, L.R. (2021) Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates. Sci. Adv. 7:eabl6026. PMID:34936441

Spliid, C.B., Toledo, A.G., Sanderson, P., Mao, Y., Gatto, F., Gustavsson, T., Choudhary, S., Saldanha, A.L., Vogelsang, R.P., Gögenur, I., Theander, T.G., Leach, F.E. 3rd, Amster, I.J., Esko, J.D., Salanti, A., Clausen, T.M. (2021) The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility. J. Biol. Chem. 297:101391. PMID:34762909

Golden, G.J., Toledo, A.G., Marki, A., Sorrentino, J.T., Morris, C., Riley, R.J., Spliid, C., Chen, Q., Cornax, I., Lewis, N.E., Varki, N., Le, D., Malmström, J., Karlsson, C., Ley, K., Nizet, V. and Esko, J.D.. (2021) Endothelial heparan sulfate mediates hepatic neutrophil trafficking and injury during Staphylococcus aureus sepsis. mBio 12:e0118121. PMID:34544271

Toledo, A.G., Sorrentino, J.T., Sandoval, D.R., Malmström, J., Lewis, N.E. and Esko, J.D. (2021) A systems view of the heparan sulfate interactome. J. Histol. Histochem. 69:105-119. PMID: 33494649.

Thacker, B.E., Thorne, K.J., Cartwright, C., Park, J., Glass, K., Chea, A., Kellman, B.P., Lewis, N.E., Wang, Z., Di Nardo, A., Sharfstein, S.T., Jeske, W., Walenga, J., Hogwood, J., Gray, E., Mulloy, B., Esko, J.D., and Glass, C.A. (2022) Multiplex Genome Editing of Mammalian Cells for Producing Recombinant Heparin. Metab. Eng. 70:155-165. PMID:35038554