Recent Relevant Publications

Sandoval, D.R., Toledo, A., Painter, C.D., Tota, E.M., Sheikh, M.O., West, A.M.V., Frank, M.M., Wells, L., Xu, D., Bicknell, R., Corbett, K.D. and Esko, J.D. (2020) Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin binding protein. J. Biol. Chem. 295:2804-2821. PMID:31964714. Selected for a special virtual issue.

Sevillano, A.M., Aguilar-Calvo, P., Kurt, T.D., Lawrence, J.A., Soldau, K., Nam, T.H., Schumann, T., Pizzo, D.P., Nyström, S., Choudhury, B., Altmeppen, H., Esko, J.D., Glatzel, M., Nilsson, K.P.R. and Sigurdson, C.J. (2020) Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease. J. Clin. Invest. 130:1350-1362. PMID:31985492; Reviewed in Bartz JC. (2020) Underglycosylated prion protein modulates plaque formation in the brain. J. Clin. Invest. 130:1350-1362 PMID:31985491

Severmann, A.C., Jochmann, K., Feller, K., Bachvarova, V., Piombo, V., Stange, R., Holzer, T., Brachvogel, B., Esko, J.D., Pap, T., Hoffmann, D. and Vortkamp, A. (2020) An altered heparan sulfate structure in the articular cartilage protects against osteoarthritis. (2020) Osteoarthritis Cartilage 28:977-987. PMID:32315715

Bachvarova, V., Dierker, T., Esko, J, Hoffmann, D., Kjellen, L. and Vortkamp, A. (2020) Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 93:43-59. PMID:32201365

Weiss, R.J., Spahn, P.N., Chiang, A.W.T., Li , J., Kellman, B.P., Benner, C., Glass, C.K., Gordts, P.L.S.M., Lewis, N.E. and Esko, J.D. (2020) ZNF263 is a novel transcriptional regulator of heparin biosynthesis. Proc. Natl. Acad. Sci. 117:9311-9317. PMID: 32277030

Toledo, A.G., Pihl, J., Spliid, C.B., Persson, A., Nilsson, J., Pereira, M.A., Gustavsson, T., Choudhary, S., Oo, H.Z., Black, P.C., Daugaard, M., Esko, J.D., Larson, G., Salanti, A. and Clausen,T.M. (2020) An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. Glycobiology 30:989-1002. PMID:32337544

Callender, J.A., Sevillano, A.M., Soldau, K., Kurt, T.D., Schumann, T., Pizzo, D.P., Altmeppen, H., Glatzel, M., Esko, J.D. and Sigurdson, C.J. (2020) Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease. Neurobiol. Dis. 142:104955. PMID:32454127

Trabszo, C., Ramms, B., Chopra, P., Lüllmann-Rauch, R., Stroobants, S., Sproß, J., Jeschke, A., Schinke, T., Boons, G.-J., Esko, J.D., Lübke, T. and Dierks, T. (2020) Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate Biochem. J. 477:3433–3451. PMID:32856704

Clausen, T.M., Sandoval, D.R., Spliid, C.B., Pihl, J., Painter, C.D., Thacker, B.E., Glass, C.A., Narayanan, A., Majowicz, S.A., Zhang, Y., Torres, J.L., Golden, G.J., Porell, R., Garretson, A.F., Laubach, L., Feldman, J., Yin, X., Pu, Y., Hauser, B., Caradonna, T.M., Kellman, B.P., Martino, C., Gordts, P.L.S.M., Leibel, S.L., Chanda, S.K., Schmidt, A.G., Godula, K., Jose, J., Corbett, K.D., Ward, A.B., Carlin, A.F. and Esko, J.D. (2020) SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2. Cell 83:1043-1057. PMID: 32699853

Spinler, K., Bajaj, J., Ito, T., Zimdahl, B., Hamilton, M., Ahmadi, A., Koechlein, C., Lytle, N., Kwon, H.Y., Anower-E-Khuda, F., Sun, H., Blevins, A., Weeks, J., Kritzik, M., Karlseder, J., Park, P.W., Ginsberg, M., Esko, J.D. and Reya, T. (2020) A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. Nat. Comm. 11:5998. PMID:33243988

Spliid ,C.B., Toledo, A.G., Salanti, A., Esko, J.D. and Clausen, T.M. (2021) Beware, commercial chondroitinases vary in activity and substrate specificity. Glycobiology 31:103-115. PMID:32573715

Marki, A., Buscher, K., Lorenzini, C., Meyer, M., Saigusa, R., Fan, Z., Yeh, Y.T., Hartmann, N., Dan, J.M., Kiosses, W.B., Golden, G.J., Ganesan, R., Winkels, H., Orecchioni, M., McArdle, S., Mikulski, Z., Altman, Y., Bui, J., Kronenberg, M., Chien, S., Esko, J.D., Nizet, V., Smalley, D., Roth, J. and Ley, K. (2021) Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. J. Exp. Med. 218:e20200551. PMID:33275138

Toledo, A.G., Sorrentino, J.T., Sandoval, D.R., Malmström, J., Lewis, N.E. and Esko, J.D. (2021) A systems view of the heparan sulfate interactome. J. Histol. Histochem. 69:105-119. PMID: 33494649

Weiss, R.J., Spahn, P.N., Chiang, A.W.T., Liu, Q., Li , J., Hamill, K.M., Rother, S., Clausen, T.M., Hoeksema, M.A., Timm, B.M., Godula, K., Glass, C.K., Tor, Y., Gordts, P.S.L.M., Lewis, N.E. and Esko, J.D. (2021) Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat. Chem. Biol.
In press.

Yuan, S., Yin, X., Meng, X., Chan, J.F., Ye, Z.W., Riva, L., Pache, L., Chan, C.C., Lai, P.M., Chan, C.C., Poon, V.K., Lee, A.C., Matsunaga, N., Pu, Y., Yuen, C.K., Cao, J., Liang, R., Tang, K., Sheng, L., Du, Y., Xu, W., Lau, C.Y., Sit, K.Y., Au, W.K., Wang, R., Zhang, Y.Y., Tang, Y.D., Clausen, T.M., Pihl, J., Oh, J., Sze, K.H., Zhang, A.J., Chu, H., Kok, K.H., Wang, D., Cai, X.H., Esko, J.D., Hung, I.F., Li, R.A., Chen, H., Sun, H., Jin, D.Y., Sun, R., Chanda, S.K. and Yuen, K.Y. (2021) Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. In press. PMID: 33727703