Recent Relevant Publications

Doody, K.M., Stanford, S.M., Sacchetti, C.D., Svensson, M.N., Coles, C.H., Mitakidis, N., Kiosses, W.B., Bartok, B., Fos, C., Cory, E., Sah, R.L., Liu-Bryan, R., Boyle, D.L., Arnett, H.A., Mustelin, T., Corr, M., Esko, J.D., Tremblay, M.L., Firestein, G.S., Aricescu, A.R. and Bottini, N. (2015) Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci. Transl. Med. 7:288. Awarded 2016 Lee C. Howley Sr. Prize for Arthritis Scientific Research, Arthritis Foundation

Coulson-Thomas, V.J., Chang, S.H., Yeh, L.K., Coulson-Thomas, Y.M., Yamaguchi, Y., Esko, J., Liu, C.Y. and Kao, W. (2015) Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest. Ophthalmol. Vis. Sci. 56:3004-3014.

Xu, D., Olson, J., Cole, J.N., van Wijk, X.M., Brinkmann, V., Zychlinsky, A., Nizet, V., Esko, J.D., and Chang, Y.C. (2015) Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity. Infect Immun. 83:3648-3656.

Weiss, R.J.*, Gordts, P.L.S.M., Le, D., Xu, D., Esko, J.D. and Tor, Y. (2015) Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions. Chem. Sci. 6:5984-5993.

Zaiss, A.K., Foley, E.M.*, Lawrence, R., Schneider, L.S., Hoveida, H., Secrest, P., Catapang, A.B., Yamaguchi, Y., Alemany, R., Shayakhmetov, D.M., Esko, J.D., and Herschman, H.R. (2015) Hepatocyte heparan sulfate is required for adeno-associated virus 2 but dispensable for adenovirus 5 liver transduction in vivo. J. Virol. 90:412-420.

Marki, A., Esko, J.D., Pries, A.R., and Ley, K. (2015) Role of the endothelial surface layer in neutrophil recruitment. J. Leukoc. Biol. 98:503-15

Varki, A., Cummings, R.D., Aebi, M, Packer, N.H., Seeberger, P.H., Esko, J.D., Stanley, P., Hart, G., Darvill, A., Kinoshita, T., Prestegard, J.J., Schnaar, R.L., Freeze, H.H., Marth, J.D., Bertozzi, C.R., Etzler, M.E., Frank, M., Vliegenthart, J.F.G., Lütteke, T., Perez, S., Bolton, E., Rudd, P., Paulson, J., Kanehisa, M., Toukach, P., Aoki-Kinoshita, K.F., Dell, A., Narimatsu, H., York, W., Taniguchi, N., and Kornfeld, S. (2015) Symbol nomenclature for graphical representations of glycans. Glycobiology 25:1323-1324.

Thacker, B.E.*, Seamen, E., Lawrence, R., Parker, M.W., Xu, Y., Liu, J., Vander Kooi, C.W., and Esko, J.D. (2016) Expanding the 3-O-sulfate proteome - Enhanced binding of neuropilin-1 to 3-O-sulfated heparan sulfate modulates its activity. ACS Chem. Biol. 11:971-980.

Hamill, K.M.*, McCoy, L.S., Wexselblatt, E., Esko, J.D. and Tor, Y. (2016) Polymyxins facilitate entry into mammalian cells. Chem. Sci. 7:5059-5068.

Gordts, P.L., Nock, R.†, Son, N.H., Ramms, B.*, Lew, I.†, Gonzales, J.C.*, Thacker, B.E.*, Basu, D., Lee, R.G., Mullick, A.E., Graham, M.J., Goldberg, I.J., Crooke, R.M., Witztum, J.L. and Esko, J.D. (2016) ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J. Clin. Invest. 26:2855-2866.

Hamill, K.M.*, Wexselblatt, E., Tong, W., Esko, J.D. and Tor, Y. (2016) Delivery of an active lysosomal enzyme using GNeosomes. J. Mater. Chem. B. 4:5794-5797.

Dwyer, C.A. and Esko, J.D. (2016) Glycan susceptibility factors in autism spectrum disorders. Mol. Aspects Med. 51:104-114.

van Wijk, X.M., Döhrmann, S., Hallström, B.M., Li, S., Voldborg, B.G., Meng, B.X.†, McKee, K.K., van Kuppevelt, T.H., Yurchenco, P.D., Palsson, B.O., Lewis, N.E., Nizet, V. and Esko, J.D. (2017) Whole genome sequencing of invasion-resistant cells identifies laminin a2 as a host factor for bacterial invasion. MBio 8:e02128-16.

Dhamale, O.P., Lawrence, R., Wiegmann, E.M., Shah, B.A., Al-Mafraji, K., Lamanna, W.C., Lübke, T., Dierks, T., Boons, G.-J. and Esko, J.D. (2017) Arylsulfatase K is the lysosomal 2-sulfoglucuronate sulfatase. ACS Chem. Biol. 12:367-373.

Dwyer, C.A., Scudder, S.L., Lin, Y., Dozier, L.E., Phan, D. Allen, N.J., Patrick, G.N. and Esko, J.D. (2017) Neurodevelopmental changes in excitatory synaptic structure and function in the cerebral cortex of Sanfilippo Syndrome IIIA mice. Sci. Rep. 7:46576.

Hamill, K.M., Wexselblatt, E., Tong, W., Esko, J.D. and Tor, Y. (2017) Delivery of cargo to lysosomes using GNeosomes. Meth. Molec. Biol. 1594:151-163.

Weiss, R.J., Esko J.D. and Tor, Y. (2017) Targeting heparin and heparan sulfate protein interactions. Org Biomol Chem. 5:5656-5668.

Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E. (2017) Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep. Aug 21;7(1):9008. doi: 10.1038/s41598-017-08720-5.

Spahn PN, Bath T, Weiss RJ, Kim J, Esko JD, Lewis NE, Harismendy O. (2017)
PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens.
Sci Rep. Nov 20;7(1):15854. doi: 10.1038/s41598-017-16193-9.

Hadidi K, Wexselblatt E, Esko JD, Tor Y. (2017) Cellular uptake of modified aminoglycosides.
J Antibiot (Tokyo). Nov 1. doi: 10.1038/ja.2017.131. [Epub ahead of print]

Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD. (2017) Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. Dec 6;25(12):2743-2752. doi: 10.1016/j.ymthe.2017.08.007. Epub 2017 Aug 12.

Phan AQ, Pacifici M, Esko JD. (2018)  Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference. Connect Tissue Res. Jan;59(1):85-98. doi: 10.1080/03008207.2017.1394295. Epub 2017 Nov 3.

Gordts PLSM, Esko JD. (2018) The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis. Matrix Biol. May 24. pii: S0945-053X(18)30188-4. doi: 10.1016/j.matbio.2018.05.010. [Epub ahead of print] Review.

Ge XN, Bastan I, Ha SG, Greenberg YG, Esko JD, Rao SP, Sriramarao P. (2018)
Regulation of eosinophil recruitment and allergic airway inflammation by heparan sulfate proteoglycan (HSPG) modifying enzymes. Exp Lung Res. Mar;44(2):98-112. doi:10.1080/01902148.2018.1451574. Epub 2018 Apr 5.

Naini SMA, Yanicostas C, Hassan-Abdi R, Blondeel S, Bennis M, Weiss RJ, Tor Y, Esko JD, Soussi-Yanicostas N. (2018) Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy. Transl Neurodegener. Mar 16;7:6. doi: 10.1186/s40035-018-0111-2. eCollection 2018.

* indicates graduate students
indicates undergraduate students