Recent Relevant Publications

  • Essentials of Glycobiology, 2nd Edition, Edited by Varki, A., Cummings, R., Esko, J.D., Freeze, H.H., Stanley, P., Bertozzi, C., Hart, G.W., and Etzler, M.E. Cold Spring Harbor Laboratory Press, New York, 2009.

  • Xu, D., Fuster, M.M., Lawrence, R., and Esko, J.D. (2011) Heparan sulfate regulates VEGF165 and VEGF121-mediated vascular hyperpermeability. J Biol Chem. 286:737-745

  • Zak, B.M.*, Schuksz, M.*, Koyama, E., Mundy, C., Wells, D.E., Yamaguchi, Y., Pacifici, M., Esko, J.D. (2011) Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones. Bone 48:979-987

  • Deng, Y.*, Foley, E.M.*, Gonzales, J.C.*, Gordts, P.L., Li, Y., Esko, J.D. (2011) Shedding of syndecan-1 from human hepatocytes alters VLDL clearance. Hepatology 55:277-86

  • Xu, D, Young, J.†, Song, D., Esko, J.D. (2011) Heparan sulfate is essential for high mobility group protein-1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE). J. Biol. Chem. 286:41736-41744

  • Sarrazin, S., Lamanna, W.C. and Esko, J.D. (2011) Heparan sulfate proteoglycans. Cold Spring Harb. Perspect. Biol. 3(7) pii: a004952 Review

  • Lawrence, R., Brown. J.R., Al-Mafraji, K., Lamanna, W.C., Beitel, J.R., Boons, G.-J., Esko, J.D. and Crawford, B.E. (2011) Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nature Chem Biol. 8:197-204 News and Views: L. Kjellén (2012) Glycobiology: Enzyme deficiencies deciphered. Nature Chem Biol 8:137-138

  • Kowalewskia, B., Lamanna. W.C., Lawrence, R., Dammea,M., Stroobantsc, S., Padvad, M., Kalusa, I., Fresea, M.A., Lübkea, T., Lüllmann-Rauche, R., D’Hoogec, R., Esko, J.D., and Dierk, T. (2012) Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc. Natl. Acad. Sci. USA 109:10310-10315

  • Bergfeld, A.K., Pearce, O.M., Diaz, S.L., Lawrence, R., Vocadlo, D.J., Choudhury, B., Esko, J.D., Varki, A. (2012) Metabolism of vertebrate amino sugars with N-glycolyl groups: Incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. J Biol Chem. 287(34):28898-916

  • Axelsson, J., Xu, D., Kang, B.N., Nussbacher, J.K.*, Handel, T.M., Ley, K., Sriramarao, P., Esko, J.D. (2012) Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 120:1742-51

  • Lamanna, W.C., Lawrence, R., Sarrazin, S., Lameda-Diaz, C.†, Gordts, P.L., Moremen, K.W., Esko, J.D. (2012) A genetic model of substrate reduction therapy for mucopolysaccharidosis. J Biol Chem. 287:36283-90.

  • Cantley, L., Saunders, C., Guttenberg, M., Candela, M.E., Ohta, Y., Yasuhara, R., Kondo, N., Sgariglia, F., Asai, S., Zhang, X., Qin, L., Hecht, J.T., Chen, D., Yamamoto, M., Toyosawa, S., Dormans, J.P., Esko, J.D., Yamaguchi, Y., Iwamoto, M., Pacifici, M., and Enomoto-Iwamoto, M. (2013) Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice. Am J Pathol. 182:917-27.

  • Inoue, M., Tong, W., Esko, J.D., and Tor, Y. (2013) Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol., in press.

  • Xu, D., Young, J.H., Krahn, J.H., Song, D., Corbett, K.D., Chazin, W.J., Pedersen, L.C. and Esko, J.D. (2013) Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol. [Epub ahead of print].

  • Gonzales, J.C.*, Gordts, P.L., Foley, E.M.* and Esko, J.D. (2013) Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J. Clin Invest., 23:2742-2751.

  • Foley, E.M.*, Gordts, P.L., Stanford, K.I.*, Gonzales, J.C.*, Lawrence, R., Stoddard, N.* and Esko, J.D. (2013) Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. Arterioscler Thromb Vasc Biol. 33:2065-2074.

  • Sugar, T., Wassenhove-McCarthy, D.J., Esko, J.D., van Kuppevelt, T.H., Holzman, L., and McCarthy, K.J. (2013) Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo. Kidney Int., in press.

  • Lawrence, R., Brown, J.R., Lorey, F., Dickson, P.I., Crawford, B.E., and Esko, J.E. (2013) Glycan-based biomarkers for Mucopolysaccharidoses. Molec. Gene. Metabolism, in press. Review

* indicates graduate students
† indicates undergraduate students