Recent Relevant Publications

  • "Essentials of Glycobiology" , Varki, A., Cummings R., Esko J., Freeze H., Hart,G and Marth J. (Eds). 1999 Cold Spring Harbor Laboratory Press , New York
  • Brown, J.R., Nishimura, Y. and Esko, J.D. (2006) Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to L-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase. Bioorg. Med. Chem. Lett., 16:532-536.
  • Brown, J.R., Fuster, M.M., Li, R, Varki, N., Glass, C.A. and Esko, J.D. (2006) A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination, Clin. Cancer Res. 12:2894-2901.
  • *Olson, S.K., Bishop, J.R., Yates, J.R., Oegema, K, and Esko, J.D. (2006) Identification of Novel Chondroitin Proteoglycans in C. elegans: Embryonic Cell Division Depends on CPG-1 and CPG-2.  J. Cell Biol. 173:985-994.
  • Pan, Y., Woodbury, A., Esko, J.D., Grobe, K., and Zhang, X. (2006) Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development 133:4933-4944.
  • Zhang, L., Lawrence, R., Frazier, B.A., and Esko, J.D. (2006) CHO Glycosylation Mutants: Proteoglycans. Methods Enzymol. 416:205-221
  • *MacArthur, J.M., Bishop, J.R., Wang, L., *Stanford, K.I., Bensadoun, A., Witztum, J.L., and Esko, J.D. (2007) Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J. Clin. Invest. 117:153-164. Commentary: Mahley, R.W. and Huang, Y. (2007) J. Clin. Invest. 117:94-98
  • Pallerla,S.R., Pan, Y., Zhang, X., Esko, J.D., and Grobe, K. (2007) Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. Dev. Dyn. 236:556-563.
  • Pönighaus, C., Ambrosius, M., Carrera-Casanova, J., Prante, C., Kuhn, J., Esko, J.D., Kleesiek, K., Götting, C. (2007) Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulphate and heparan sulphate proteoglycans. J. Biol. Chem. 282:5201-5206.
  • *Elson-Schwab, L., *Garner, O.B.,* Schuksz, M., *Crawford, B.E., Esko, J.D., and Tor, Y.  (2007) Guanidinylated-Neomycin delivers large, bioactive cargo into cells through a heparan sulfate dependent pathway. J. Biol. Chem. 282:13585-13591.
  • Borsig, L., Wang, L., Cavalcante, M.C., Cardilo-Reis, L., Ferreira, P.L., Mourao, P.A., Esko, J.D., and Pavao, M.S. (2007) Selectin-blocking activity of a fucosylated chondroitin sulfate glycosaminoglycan from sea-cucumber: Effect on tumor metastasis and neutrophil recruitment. J. Biol. Chem. 282:14984-14989.
  • Fuster, M.M., Wang, L., Castagnola, J., Sikora, L., Reddi, K., Lee, P.H.A., Radek, K., Gallo, R.L., Sriramarao, P. and Esko, J.D. (2007) Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis. J. Cell Biol. 177:539-549.
  • Bode, L., Salvestrini, C., Park, P.W., Li, J.-P,  Esko, J.D., Murch, S., Freeze, H.H. (2007) Heparan sulfate and syndecan-1 are essential in maintaining intestinal epithelial barrier function. J. Clin. Invest. 118:229-238.
  • Bishop, J.R., *Schuksz, M., and Esko, J.D. (2007), Heparan sulfate proteoglycans fine-tune mammalian physiology.  Nature 446:1030-1037
  • Coppi, A., Tewari, R., Bishop, J.R., Bennett, B.L., Lawrence, R., Esko, J.D., Billker, O. and Sinnis, P. (2007) Heparan sulfate proteoglycans provide a signal to plasmodium sporozoites to stop migrating and productively invade cells. Cell Host Microbe 2:316-327. Commentary: Miguel Prudéncio, M. and Mota, M.M. (2007) To migrate or to invade: those are the options. Cell Host Microbe 2:286-288.
  • Pan, Y., Carbed, C., Powers, A., Esko, J.D., Grobe, K., Feng, G.-S. and Zhang, X. (2007) Bud specific N-sulfation of heparan sulfate regulates Shp2 dependent FGF signaling during lacrimal gland induction. Development, 135:301-10.
  • Brown, J.R., Crawford, B.E., and Esko, J.D. (2007) Glycans: A fount for drug discovery. Crit. Rev. Biochem. Mol. Biol. 42:481 - 515. 

* indicates graduate students