Recent Relevant Publications

Wen, J., Xiao, J., Rahdar, M., Choudhury, B.P., Cui, J., Taylor, G.S., Esko, J.D., and Dixon, J.E. (2014) Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A 111:15723-15728

Gordts, P.L.S.M., Foley, E.*, Lawrence, R., Sinha, R., Lameda-Diaz, C., Deng, L., Nock, R., Glass, C.K., Erbilgin, A., Lusis, A.J., Witztum, J.L. and Esko, J.D. (2014) Reducing Macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced Type I interferon signaling. Cell Metab. 20, 813–826. Highlighted in: N. R. Gough (2014) Heparan sulfate proteoglycans control basal inflammation. 
Sci. Signal. 7, ec320

Thacker, B.E.*, Xu, D., Lawrence, R. and Esko, J.D. (2014) Heparan sulfate 3-O-sulfation: A structure in search of a function. Matrix Biol. 35:60-72

Lawrence, R., Brown, J.R., Lorey, F., Dickson, P.I., Crawford, B.E., and Esko, J.D. (2014) Glycan-based biomarkers for mucopolysaccharidoses. Molec. Gene. Metabolism 111:73-83

Xu, D. and Esko, J.D. (2014) Demystifying heparan-sulfate protein interactions.
Ann. Rev. Biochem. 83:129-57

Wexselblatt, E., Esko, J.D., and Tor, Y. (2015) GNeosomes: Highly lysosomotropic nanoassemblies for lysosomal delivery. ACS Nano. 9:3961-3968.

Akizu, N., Cantagrel, V., Zaki, M.S., Al-Gazali, L., Wang, X., Rosti, R.O., Dikoglu, E., Gelot, A.B., Rosti, B., Vaux, K.K., Scott, E.M., Silhavy, J.L., Schroth, J., Copeland, B., Schaffer, A.E., Gordts, P.L., Esko, J.D., Buschman, M.D., Field, S.J., Napolitano, G., Abdel-Salam, G.M., Ozgul, R.K., Sagiroglu, M.S., Azam, M., Ismail, S., Aglan, M., Selim, L., Mahmoud, I.G., Abdel-Hadi, S., Badawy, A.E., Sadek, A.A., Mojahedi, F., Kayserili, H., Masri, A., Bastaki, L., Temtamy, S., Müller, U., Desguerre, I., Casanova, J.L., Dursun, A., Gunel, M., Gabriel, S.B., de Lonlay, P., and Gleeson, J.G. (2015) Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat. Genet. 47:528-534.

Doody, K.M., Stanford, S.M., Sacchetti, C.D., Svensson, M.N., Coles, C.H., Mitakidis, N., Kiosses, W.B., Bartok, B., Fos, C., Cory, E., Sah, R.L., Liu-Bryan, R., Boyle, D.L., Arnett, H.A., Mustelin, T., Corr, M., Esko, J.D., Tremblay, M.L., Firestein, G.S., Aricescu, A.R. and Bottini, N. (2015) Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci. Transl. Med. 7:288. Awarded 2016 Lee C. Howley Sr. Prize for Arthritis Scientific Research, Arthritis Foundation

Coulson-Thomas, V.J., Chang, S.H., Yeh, L.K., Coulson-Thomas, Y.M., Yamaguchi, Y., Esko, J., Liu, C.Y. and Kao, W. (2015) Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. Invest. Ophthalmol. Vis. Sci. 56:3004-3014.

Xu, D., Olson, J., Cole, J.N., van Wijk, X.M., Brinkmann, V., Zychlinsky, A., Nizet, V., Esko, J.D., and Chang, Y.C. (2015) Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity. Infect Immun. 83:3648-3656.

Weiss, R.J.*, Gordts, P.L.S.M., Le, D., Xu, D., Esko, J.D. and Tor, Y. (2015) Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions. Chem. Sci. 6:5984-5993.

Zaiss, A.K., Foley, E.M.*, Lawrence, R., Schneider, L.S., Hoveida, H., Secrest, P., Catapang, A.B., Yamaguchi, Y., Alemany, R., Shayakhmetov, D.M., Esko, J.D., and Herschman, H.R. (2015) Hepatocyte heparan sulfate is required for adeno-associated virus 2 but dispensable for adenovirus 5 liver transduction in vivo. J. Virol. 90:412-420.

Thacker, B.E.*, Seamen, E., Lawrence, R., Parker, M.W., Xu, Y., Liu, J., Vander Kooi, C.W., and Esko, J.D. (2016) Expanding the 3-O-sulfate proteome - Enhanced binding of neuropilin-1 to 3-O-sulfated heparan sulfate modulates its activity. ACS Chem. Biol. 11:971-980.

Hamill, K.M.*, McCoy, L.S., Wexselblatt, E., Esko, J.D. and Tor, Y. (2016) Polymyxins facilitate entry into mammalian cells. Chem. Sci. 7:5059-5068.

Gordts, P.L., Nock, R.†, Son, N.H., Ramms, B.*, Lew, I.†, Gonzales, J.C.*, Thacker, B.E.*, Basu, D., Lee, R.G., Mullick, A.E., Graham, M.J., Goldberg, I.J., Crooke, R.M., Witztum, J.L. and Esko, J.D. (2016) ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J. Clin. Invest. 26:2855-2866.

Hamill, K.M.*, Wexselblatt, E., Tong, W., Esko, J.D. and Tor, Y. (2016) Delivery of an active lysosomal enzyme using GNeosomes. J. Mater. Chem. B. 4:5794-5797.

Dwyer, C.A. and Esko, J.D. (2016) Glycan susceptibility factors in autism spectrum disorders. Mol. Aspects Med. 51:104-114.

van Wijk, X.M., Döhrmann, S., Hallström, B.M., Li, S., Voldborg, B.G., Meng, B.X.†, McKee, K.K., van Kuppevelt, T.H., Yurchenco, P.D., Palsson, B.O., Lewis, N.E., Nizet, V. and Esko, J.D. (2017) Whole genome sequencing of invasion-resistant cells identifies laminin a2 as a host factor for bacterial invasion. MBio 8:e02128-16.

Dhamale, O.P., Lawrence, R., Wiegmann, E.M., Shah, B.A., Al-Mafraji, K., Lamanna, W.C., Lübke, T., Dierks, T., Boons, G.-J. and Esko, J.D. (2017) Arylsulfatase K is the lysosomal 2-sulfoglucuronate sulfatase. ACS Chem. Biol. In press.

* indicates graduate students
indicates undergraduate students